Saturday June 10, 2023 |
15:00 | Registration |
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| Opening Session |
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17:30 | Opening of the Symposium and Welcome address |
Prof. Daniel HARKI (UNIVERSITY OF MINNESOTA, Minneapolis, MN, United States) |
17:45 | PL01- Medicinal Chemistry of the Future: Trends, Targets and Technologies |
Dr Klaus URBAHNS (EMD SERONO, Billerican, MA, United States) |
18:30 | Welcome Reception |
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Sunday June 11, 2023 |
08:00 | Registration |
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| Session 1 - Chemical Modulation of RNA |
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| Session chair |
Dr Darby SCHMIDT (SONATA THERAPEUTICS, Cambridge, MA, United States) |
09:00 | IL01 - Modulating the Conformation and Function of Disease-Relevant RNA with Small Molecules |
Prof. Amanda HARGROVE (DUKE UNIVERSITY, Durham, NC, United States) |
09:30 | IL02 - Targeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies |
Dr Maria DUCA (UNIVERSITY OF CÔTE D'AZUR, Nice, France) |
10:00 | IL03 - Discovery and Development of Selective Splicing Modifiers as Therapeutics |
Dr Matthew WOLL (PTC THERAPEUTICS, South Plainfield, NJ, United States) |
10:15 | IL04 - Small Molecules Targeting RNA - a Safety Perspective |
Dr Helen Louise LIGHTFOOT (F. HOFFMANN-LA ROCHE AG, BASEL, Switzerland) |
10:30 | Coffee break & Exhibition |
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| Session 2 - Advances in Targeted Protein Degradation |
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| Session chair |
Prof. Terry MOORE (UNIVERSITY OF ILLINOIS, Chicago, IL, United States) |
11:00 | IL05 - Ligand Directed Degradation: from Proof-of-Concept Degradation to Clinical Studies |
Dr Deborah MORTENSEN (BRISTOL MYERS SQUIBB, San Diego, CA, United States) |
11:30 | IL06 - Chemical Approaches to Edit Post-Translational Modification In Cells |
Prof. Christina WOO (HARVARD UNIVERSITY, Cambridge, MA, United States) |
12:00 | OC01 - Treatment of Pediatric AML Via Protac-Mediated Degration of CDK9 |
Ms Alexandria CHAN (UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY, Baltimore, United States) |
12:15 | OC02 - Targeting Progerin Degradation as a New Therapeutic Approach for Treating Progeria |
Prof. Silvia ORTEGA-GUTIERREZ (COMPLUTENSE UNIVERSITY, Madrid, Spain) |
12:30 | Lunch & Exhibition |
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12:45 | Company Workshop by Pelago Bioscience: CETSA® Enabled Drug Discovery: An Applied Workshop on Target Identification/Validation and Target Engagement-Driven Lead Generation and Optimization |
Dr Fredrik RAHM (PELAGO BIOSCIENCE, Solna, Sweden) Dr Stina LUNDGREN (PELAGO BIOSCIENCE, Solna, Sweden) |
| Session 3 - Proximity-inducing Molecules and their Therapeutic Applications |
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| Session chair |
Dr Amit CHOUDHARY (THE BROAD INSTITUTE, Cambridge, MA, United States) |
14:00 | IL07 -Chemoproteomic-Enabled Development of Proximity-Inducing Molecules |
Dr Christopher PARKER (THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA, United States) |
14:30 | IL08 - An Intramolecular Bivalent Degrader Glues an Intrinsic BRD4-DCAF16 Interaction |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
15:00 | OC03 - Discovery of MRT-2359, an Orally Bioavailable GSPT1 Molecular Glue Degrader, for MYC-Driven Cancers
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Dr Bernhard FASCHING (MONTE ROSA THERAPEUTICS, Basel, Switzerland) |
15:15 | OC04 - Integrated Platform Approach for Molecular Degrader Discovery in Proxidrugs
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Dr Johanna HUCHTING (FRAUNHOFER INSTITUTE FOR TRANSLATIONAL MEDICINE AND PHARMACOLOGY, Hamburg, Germany) |
15:30 | Coffee break & Exhibition |
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16:00 | PL02 - RIPTACs: A New ‘Hold and Kill’-based Therapeutic Modality
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Prof. Craig CREWS (YALE UNIVERSITY, New Haven, CT, United States) |
16:45 | Poster session 1 (odd numbers) |
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18:00 | End of the scientific programme |
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18:10 | City Tour |
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Monday June 12, 2023 |
08:00 | ACMEDI-YMCC | EFMC-YSN Programme for Early Career Researchers |
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| Chair |
Dr Melissa GRENIER-DAVIES (GLAXOSMITHKLINE, Cambridge, MA, United States) |
08:00 | Panel Discussion - "Landing a Job in Industry" |
Dr Chris DE GRAAF (SOSEI HEPTARES, Cambridge, United Kingdom) Dr Abdellatif EL MARROUNI (MERCK & CO., West Point, United States)  (SANOFI-AVENTIS DEUTSCHLAND GMBH) Dr Malin LEMURELL (ASTRAZENECA, Gothenburg, Sweden) Dr Darby SCHMIDT (SONATA THERAPEUTICS, Cambridge, MA, United States) |
| Session 4 - Drug Targets in GPCR Signaling |
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| Session chair |
Prof. György KESERU (HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary) |
09:00 | IL09 - New Hot Targets? Medicinal Chemistry of G Protein-Coupled Receptors Involved in Immunity and Cancer |
Prof. Christa MÜLLER (UNIVERSITY OF BONN, Bonn, Germany) |
09:30 | IL10 - Frontier SBDD across the Orthosteric and Allosteric GPCRome |
Dr Chris DE GRAAF (SOSEI HEPTARES, Cambridge, United Kingdom) |
10:00 | OC05 - Best-In-Class Orally Bioavailable CXCR4 Antagonists to Treat Renal Cell Carcinoma |
Dr Eric MILLER (EMORY UNIVERSITY SCHOOL OF MEDICINE, Atlanta, United States) |
10:15 | OC06 - Targeting Sodium Binding Pocket in Mu Opioid Receptor to Design Safer Analgesics |
Dr Susruta MAJUMDAR (UHSP & WASHINGTON UNIVERSITY, Saint Louis, United States) |
10:30 | Coffee break & Exhibition |
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| Session 5 - Organic Synthesis Impacting Medicinal Chemistry & Chemical Biology |
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| Session chair |
Prof. Rui MOREIRA (UNIVERSITY OF LISBON, Lisbon, Portugal) |
11:00 | IL11 - Photocatalysis in the Pharmaceutical Industry: Synthesis under a New Light |
Dr Giulia BERGONZINI (ASTRAZENECA, Gothenburg, Sweden) |
11:30 | IL12 - HTE Chemistry to Accelerate Medicinal Chemistry Programs |
Dr Fabio LIMA (NOVARTIS, Basel, Switzerland) |
12:00 | OC07 - New Precision Anti-TB Agents by Allosteric Inhibition of Glutamate-5-Kinase Enzyme |
Prof. Concepcion GONZALEZ-BELLO (UNIVERSIDADE DE SANTIAGO DE COMPOSTELA - CIQUS, santiago de compostela, Spain) |
12:15 | OC08 - Impact of gem-Difluoromethylene Group on Physicochemical Properties in Medchem-Relevant Building Blocks |
Dr Sergey RYABUKHIN (ENAMINE LTD, Kyiv, Ukraine) |
12:30 | Lunch & Exhibition |
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12:45 | Company Workshop by Schrödinger: Augmenting Medicinal Chemistry with Digital Chemistry: A Lead Optimization Design Challenge for D-Amino Acid Oxidase Inhibitors |
Mr Wade MILLER (SCHRÖDINGER, Cambridge, United States) |
| Session 6 - Enabling Chemistries for Chemical Biology Research |
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| Session chair |
Prof. Daniel HARKI (UNIVERSITY OF MINNESOTA, Minneapolis, MN, United States) |
14:00 | IL13 - Chemical Probes Enabling Drug Target Discovery and Validation |
Prof. Edward TATE (IMPERIAL COLLEGE LONDON, London, United Kingdom) |
14:30 | IL14 - Generating Stem-Like T Cells with Small-Molecule Modulators for Cancer Immunotherapy |
Prof. Peng WU (THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA, United States) |
15:00 | OC09 - Targeting Receptor Complexes with Therapeutic Peptides |
Prof. Kristian STROMGAARD (UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark) |
15:15 | OC10 - Azetidin-2-Ones as Quenched Activity-Based Probes to Profile Human Neutrophil Elastase in Proteomes |
Ms Rita FÉLIX (IMED.ULISBOA - RESEARCH INSTITUTE FOR MEDICINES, Lisbon, Portugal) |
15:30 | Coffee break & Exhibition |
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16:00 | PL03 -Carbohydrates in Health and Disease |
Prof. Laura KIESSLING (MIT, Cambridge, MA, United States) |
16:45 | Poster session 2 (even numbers) |
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18:00 | End of the scientific programme |
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20:00 | Banquet (optional) |
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Tuesday June 13, 2023 |
| Session 7 - A Focus on Early Career Investigators |
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| Session chair |
Dr Melissa GRENIER-DAVIES (GLAXOSMITHKLINE, Cambridge, MA, United States) |
09:00 | IL15 - E3 Ligase Ligand Discovery for TPD |
Dr Benika PINCH (NOVARTIS, Cambridge, MA, United States) |
09:15 | IL16 - Chemical Approaches to Enhance Cellular Immunotherapies |
Dr Mark P. FARRELL (UNIVERSITY OF KANSAS, Lawrence, KS, United States) |
09:30 | IL17 - Machine Learning Tools to Accelerate Chemical Biology Studies |
Dr Tiago RODRIGUES (UNIVERSITY OF LISBON, Lisbon, Portugal) |
09:45 | OC11 - Chemical Probes for RHO GEF/GTPase Complexes |
Ms Mia CALLENS (UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
10:00 | OC12 - Potent Targeted Activator of Cell Kill Molecules Selectively Eliminate HIV Infected Cells |
Dr Abdellatif EL MARROUNI (MERCK & CO., West Point, United States) |
10:15 | OC13 - Borrowing Transcriptional Kinases to Activate Apoptosis Using Chemically Induced Proximity |
Dr Roman SAROTT (STANFORD UNIVERSITY, Menlo Park, United States) |
10:30 | Coffee break & Exhibition |
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| Session 8 - Approaches to Identify and Target Cryptic and Allosteric Pocket |
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| Session chair |
Dr Malin LEMURELL (ASTRAZENECA, Gothenburg, Sweden) |
11:00 | IL18 - A Computation-First Approach to Drug Challenging Disease Targets |
Dr Woody SHERMAN (PSIVANT THERAPEUTICS, Boston, MA, United States) |
11:30 | IL19 - X-ray Crystallographic Fragment Screening for the Identification of Allosteric Binding Sites |
Dr Andrew WOODHEAD (ASTEX THERAPEUTICS, Cambridge , United Kingdom) |
12:00 | IL20 - Exploiting Allostery for Computer-Aided Drug Design of Oncogenes |
Dr Zoe COURNIA (BIOMEDICAL RESEARCH FOUNDATION ACADEMY OF ATHENS, Athens, Greece) |
12:30 | OC14 - Structure-Based Drug Discovery and Umbrella Sampling Simulations Identify Novel Potent Troponin Calcium Sensitizers and Elucidate their Function |
Prof. Steffen LINDERT (OSU, Columbus, United States) |
12:45 | Lunch & Exhibition |
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13:00 | Company Workshop by CAS: The Evolution of Science at CAS: Connections Between Multi-disciplinary Data and Capabilities |
Mrs Vee LINDSAY (CAS, Columbus, United States) Dr Angela ZHOU (CAS, Columbus, United States) |
| Session 9 - Getting Out of the Starting Block: New Hit Finding and Chemotype Advancement Methods |
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| Session chair |
Dr Carolyn DZIERBA (BRISTOL-MYERS SQUIBB, Cambridge, MA, United States) |
14:00 | IL21 - RAPID – a Next-Generation Chemoproteomics Technology Enabling the Discovery of Reversible Binders to Pre-specified Targets in Living Cells |
Dr Justin RETTENMAIER (JNANA THERAPEUTICS, Boston, MA, United States) |
14:30 | IL22 - Covalent Fragment-Based Drug Discovery |
Dr Daniel ERLANSON (FRONTIER MEDICINES, South San Francisco, CA, United States) |
15:00 | IL23 - Large-scale in Silico Fragment Screening of ~200 Million Fragments Based on Absolute Free Energy Perturbation |
Dr Eric THERRIEN (SCHRODINGER, New York, NY, United States) |
15:15 | OC15 - Small Molecule Drug Discovery with Peptide-Encoded Libraries |
Dr Nathalie GROB (MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, United States) |
16:00 | Closing Ceremony & Poster Prizes Ceremony |
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16:30 | End of the Symposium |
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19:10 | Boston Red Sox's game (optional) |
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