EFMC-YMCS 2019

6th EFMC Young Medicinal Chemist Symposium

 Athens, Greece    September 5-6, 2019

Programme


14:15

Registration

15:00

Welcome and Opening

Session Chair:

Dr Emmanouil FOUSTERIS
UNIVERSITY OF PATRAS, Patras, Greece

15:05

KL01 - The Emergence of Antibody-Drug Conjugates (ADCs) as Targeted Cancer Therapies: From Ehrlich's "Magic Bullet" Concept to Calicheamicin γ1I and Mylotarg

Prof. K.C. NICOLAOU
RICE UNIVERSITY, Houston, United States

EFMC-YMCS Competition Presentation Session I

15:35

OC01 - Functionalization of Tumour-Targeting Antibodies Via Enzymatic Oxidation of Tyrosine to 1,2-Quinones
Winner of the Young Medicinal Chemist Meeting in The Netherlands

Mr Jorick BRUINS
WAGENINGEN UNIVERSITY, WAGENINGEN, The Netherlands

15:55

OC02 - Synthetic Small Molecules Interfering with Oncogenic Micrornas for the Induction of Glioblastoma Stem Cells Differentiation
Winner of the Young Medicinal Chemist Meeting in France

Ms Chloé MAUCORT
INSTITUTE OF CHEMISTRY OF NICE, Nice, France

16:15

OC03 -New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies to Fight Metastatic Breast Cancer
Winner of the Young Medicinal Chemist Meeting in Portugal

Dr Leonor CORTE-REAL
CENTRO DE QUÍMICA ESTRUTURAL, Lisboa, Portugal

16:35

Flash Poster Presentations (01-10)

FP01 - A New Life for Diazaborines: the Next Generation of Serine Protease Inhibitors

Mr Joao ANTONIO
UNIVERSITY OF LISBON, Lisbon, Portugal

FP02 - From Peptides to Peptidomimetics: Structure-Activity Relationship of a Factor H-Binding Peptide to Modulate Undesired Host Complement Activity

Mr Clément BECHTLER
UNIVERSITY OF BASEL, Basel, Switzerland

FP03 - Matrix Metalloproteinase-12 Inhibitors: Synthesis, Structure-Activity Relationships and Intestinal Absorption of Novel Sugar-Based Biphenylsulfonamide Carboxylates

Dr Doretta CUFFARO
UNIVERSITY OF PISA, Pisa, Italy

FP04 - Photophysical Properties and Antiparasitic Activity of Bodipy-Tethered Dinuclear Trithiolato-Bridged Ruthenium(II)-Arene Complexes

Mrs Oksana DESIATKINA
UNIVERSITY OF BERN, Bern, Switzerland

FP05 - N-ALKYL L-Iminosugars as Novel Anti-Inflammatory and Anti-Biofilm Tools for Cystic Fibrosis Lung Infections

Ms Anna ESPOSITO
UNIVERSITY OF NAPOLI FEDERICO II, Napoli, Italy

FP06 - Design, Synthesis and Biological Evaluation of Novel Substituted Purine Isosters as EGFR Kinase Inhibitors, with Promising Pharmacokinetic Profile and In Vivo Efficacy

Dr Efthymios-Spyridon GAVRIIL
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece

FP07 - Metal-Chelating Acetohydroxamic Acids Against Hepatitis C Virus and Flaviviruses

Ms Erofili GIANNAKOPOULOU
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece

FP08 - Discovery of Small-Molecule Modulators of 14-3-3 PPIs Via Dynamic Combinatorial Chemistry

Mr Alwin HARTMAN
UNIVERSITY OF GRONINGEN, Groningen, The Netherlands

FP09 - Purine Nucleoside Analogs as Highly Potent Leads for the Treatment of Human African Trypanosomiasis

Mr Fabian HULPIA
UGENT, Ghent, Belgium

FP10 - Development of Allosteric Inhibitors of ColH Using DCC Strategy

Dr Jelena KONSTANTINOVIC
HELMHOLTZ INSTITUTE FOR PHARMACEUTICAL RESEARCH SAARLAND (HIPS), Saarbrücken, Germany

16:55

Coffee Break

EFMC-YMCS Competition Presentation Session II

Session Chair:

Dr Kristina GONCHARENKO
SPIROCHEM AG, Basel, Switzerland

17:10

OC04 - Novel Acridine Derivatives as TDP 1 and/or 2 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Greece

Mrs Maria KARELOU
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece

17:30

OC05 - Discovery of a Novel Chemotype of Non-Acidic, Neutral and Macrocyclic Keap1 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Sweden

Mr Fabio BEGNINI
UPPSALA UNIVERSITY, Uppsala, Sweden

17:50

OC06 - Directed Evolution of Short Peptides for Selective Detoxification of Lead
Winner of the Young Medicinal Chemist Meeting in Switzerland

Dr Michal SHOSHAN
ETH ZÜRICH, Zürich, Switzerland

18:10

Flash Poster Presentations (11-20)

FP11 - Identification, Synthesis and Optimization of Inhibitors of the Protein Tyrosine Phosphatase SHP2

Dr Yelena MOSTINSKI
LEIBNIZ-FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE, Berlin, Germany

FP12 - Multitarget Triazoles: an Innovative Approach for the Treatment of Alzheimer’s Disease

Ms Vanesa NOZAL GARCIA
CIB - CSIC, Madrid, Spain

FP13 - TDP-43 Modulation by CDC7 Inhibitors as a Therapeutic Strategy for Amyotrophic Lateral Sclerosis

Ms Elisa ROJAS
CIB - CSIC, Madrid, Spain

FP14 - Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool in the Development of Selective Ligands for Subtypes Ampa Receptor

Dr Stefano SAINAS
UNIVERSITY OF TORINO, Torino, Italy

FP15 - In Vitro and In Ovo Evaluation of Ros-Activatable Anticancer Boronate Prodrugs of Doxorubicin

Dr Charles SKARBEK
UNIVERSITY PARIS SUD, Orsay, France

FP16 - Design and Synthesis of Tead's Ligands for the Treatment of Cancers

Mrs Manon STURBAUT
UNIVERSITY OF LILLE, Lille, France

FP17 - Drug-Fragment Based Explorations for Novel Enterovirus Inhibitors

Ms Clara VAN HOEY
UNIVERSITY OF VIENNA, Vienna, Austria

FP18 - Gemcitabine-GnRH Bioconjugates Bearing Oxime Bond Linkages: Synthesis, In Vitro Stability, Drug Release and Cytotoxic Effect

Mr Eirinaios VRETTOS
UNIVERSITY OF IOANNINA, Ioannina, Greece

FP19 - Development of GSTO1-1 Inhibitors for the Treatment of Inflammatory Conditions

Ms Yiyue XIE
MONASH UNIVERSITY, Melbourne, Australia

FP20 - Identification of a Novel Quinoline-Based DNA Demethylating Compound Highly Potent in Cancer Cells

Dr Clemens ZWERGEL
UNIVERSITY OF ROME LA SAPIENZA, Rome, Italy

18:30

EFMC-YMCS Poster Presentation Session 1 (Odd), Bites & Drinks

19:30

EFMC-YMCS Poster Presentation Session 2 (Even), Bites & Drinks

20:30

End of the Scientifc Programme

EFMC-YSN Soft Skills Training Session (1)

20:30

How to Boost Your Oral Presentation Skill, and Create a Good Slideshow

Dr Kristina GONCHARENKO
SPIROCHEM AG, Basel, Switzerland

20:45

Getting the Job You Deserve!

Dr. David ALKER
DAVID ALKER ASSOCIATES, Birchington, United Kingdom

21:15

EFMC-YSN Networking Event

22:30

End of the Day

EFMC-YMCS Competition Presentation Session III

Session Chair:

Dr Cassandra LEE FLEMING
UNIVERSITY OF GOTHENBURG, Gothenburg, Sweden

08:30

KL02 - Medicinal Chemistry Between Serendipity and (Artificial) Intelligence

Dr Cornelia ZUMBRUNN
IDORSIA PHARMACEUTICALS, Allschwil, Switzerland

09:00

OC07 - Antiplasmodial Activity of SAHAquines, Novel SAHA - Primaquine Hybrids
Winner of the Young Medicinal Chemist Meeting in Croatia

Ms Maja BEUS
UNIVERSITY OF ZAGREB, Zagreb, Croatia

09:20

OC08 - Hybrdization Approach Towards Novel Antituberculars: Design, Synthesis, And Antimicrobial Evaluation Hybrid Compounds Combining Pyrazinamide and p Aminosalicylic Acid
Winner of the Young Medicinal Chemist Meeting in Czech Republic

Ms Ghada BOUZ
CHARLES UNIVERSITY, Hradec Kralove, Czech Republic

09:40

OC09 - Synthesis, Computational and Biological Evaluation of Novel Benzimidazole Compounds for the Treatment of Cryptococcus Neoformans
Winner of the Young Medicinal Chemist Meeting in the United Kingdom

Ms Gina WASHBOURN
UNIVERSITY OF LIVERPOOL, Liverpool, United Kingdom

10:00

OC10 - Nʼ-Benzylated Derivatives of N-(7-Chloroquinolin-4-Yl)Octane-1,8-Diamine as Quorum Sensing Inhibitors in Pseudomonas Aeruginosa
Winner of the Young Medicinal Chemist Meeting in Serbia

Ms Marta SPASIC
UNIVERSITY OF BELGRADE, Nis, Serbia

10:20

Coffee Break

EFMC-YMCS Competition Presentation Session IV

Session Chair:

Dr Eleni PONTIKI
ARISTOTELE UNIVERSITY OF THESSALONIKI, Thessaloniki, Greece

10:40

OC11 - Geometric Isomers of N-Propargyl-4-Syrylpiperidine Discriminate Between Monoamine Oxidase Isoforms A and B
Winner of the Young Medicinal Chemist Meeting in Slovenia

Dr Damijan KNEZ
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

11:00

OC12 A Fusing Strategy Application: Towards Potent ChE Inhibitors With MTDL Profile
Winner of the Young Medicinal Chemist Meeting in Turkey

Ms Gülsah BAYRAKTAR
EGE UNIVERSITY FACULTY OF PHARMACY, Izmir, Turkey

11:20

OC13 - Development of Unique Molecular Probes: Low-Basicity Agonists for the Study of 5-HT7 Receptor Function
Winner of the Young Medicinal Chemist Meeting in Poland

Dr Adam HOGENDORF
MAJ INSTITUTE OF PHARMACOLOGY, POLISH ACADEMY OF SCIENCES, Krakow, Poland

11:40

OC14 - The Establishment of Tocopherol Reference Intervals for Hungarian Adult Population Using Validated HPLC Method
Winner of the Young Medicinal Chemist Meeting in Hungary

Dr Gábor VERES
HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary

12:00

Lunch

EFMC-YSN Soft Skills Training Session (2)

13:00

Why Was My Paper Rejected? Tips from an Editor on How to Get Published

Dr David PERALTA
WILEY-VCH VERLAG GMBH & CO. KGAA, Weinheim, Germany

EFMC-YMCS Competition Presentation Session V

13:45

Session Chair:

Prof. Grigorios ZOIDIS
UNIVERSITY OF ATHENS, Athens, Greece

13:45

OC15 - Expanding the Chemical Space of DNA-Encoded Small Molecule Libraries
Winner of the Young Medicinal Chemist Meeting in Germany

Dr Andreas BRUNSCHWEIGER
TU DORTMUND, Dortmund, Germany

14:05

OC16 - Finding the Right Candidate for the Right Position: a Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders
Winner of the Young Medicinal Chemist Meeting in Spain

Dr Andrés GONZALEZ SANTANA
IQOG - CSIC, Madrid, Spain

14:25

OC17 - From ZINC to ZINClick: Our Way to Explore the Chemical Space
Winner of the Young Medicinal Chemist Meeting in Italy

Dr Alberto MASSAROTTI
UNIVERSITY OF EASTERN PIEDMONT, Novara, Italy

14:45

OC18 - Extended Glucuronides: Achieving Site-Selectivity Through Extracellular Drug Release
Winner of the Young Medicinal Chemist Meeting in Denmark

Mr Raoul WALTHER
AARHUS UNIVERSITY, Aarhus, Denmark

15:05

OC19 - Cyclopropenium-Based Polymers
Winner of the Young Medicinal Chemist Meeting in Israel

Mr Noam STEINMAN
HEBREW UNIVERSITY OF JERUSALEM, Jerusalem, Israel

15:25

Voting Break

15:40

KL03 - Chemical Tools to Target and Image Tumours

Prof. Stuart CONWAY
UNIVERSITY OF OXFORD, Oxford, United Kingdom

16:10

Closing and Award Ceremony

16:20

End of the Symposium