Registration

Welcome and Opening

KL01 - "All Models are Wrong, Some are Useful". The Medicinal Chemist is Never Better Than the Biological Models Available to Assess Compound Properties

Session Chair:

OC01 - Degrading Into Opportunities: Self-Immolation as Mechanism for Artificial Signal Transduction
Winner of the young medicinal chemist meeting in Denmark

OC02 - From a Helix to a Cycle: Peptide Macrocylization Strategies to Develop New Antimicrobial Agents
Winner of the young medicinal chemist meeting in Italy

OC03 - Disruption of Mitochondrial Redox Homeostasis by Enzymatic Activation of a Trialkylphosphine Probe
Winner of the young medicinal chemist meeting in Switzerland

Flash Poster Presentations (Part I)

FP01 – Triazine-Based Small Molecules as Novel PD-L1 Modulators

FP02 - Synthesis and Preclinical Validation of Limks Inhibitors: Promising Drugs for Osteosarcoma Treatment?

FP03 - Development of Encoded Combinatorial Chemistry for The Identification of Specific Ligands of G-Quadruplex DNA Structures

FP04 - Synthesis and Biological Activity of Novel Azoniaspiro Type Quaternary Fluoroquinolones

FP05 - Development of Novel Necroptosis Inhibitors Targeting RIPK1

FP06 - Discovery of JNJ-1245, a Novel and Potent Fluoroallylamide MCL-1 Inhibitor for the Treatment of Hematologic Malignancies

FP07 - Target-Directed Dynamic Combinatorial Chemistry Towards the Discovery of Sars-Cov-2 Anti-Virals Targeting NSP10

FP08 - Panicein a Hydroquinone and Analogs Overcome Chemotherapy Resistance in Cancer Cell

FP09 - Development of Bioorthogonal Palladium Catalysed Reactions for Specific Anticancer Drug Delivery

FP10 - Design, Synthesis & Evaluation of Novel Aminopeptidase Inhibitors as Potent Antimalarials

FP15 - Synthesis and Biological Evaluation of Schistosoma Mansoni Sirtuin2 (SMSIRT2) Inhibitors

FP16 - Design, Synthesis and Biological Evaluation of New Rna Ligands Targeting miRNA-210: Modulation of the Circadian Clock for Cancer Therapy

FP17 - A Small Fluorescent Ligand to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells

FP18 - Bactericidal Autophagy Inhibitors to Treat Recurrent Infections and Cancer

Coffee Break & Exhibition

Session Chair:

OC04 - Epitope Identification, a Case Study: Nanobodies Binding to MGLU5 Receptor
Winner of the young medicinal chemist meeting in France

OC05 - Studies on the Synthesis and Anticancer Potential of Novel 2,4-Diaminopyrimidine Derivatives
Winner of the young medicinal chemist meeting in Turkey

OC06 - Unraveling the Potential of Multicomponent Reactions in Drug Discovery
Winner of the young medicinal chemist meeting in Spain

EFMC-YMCS Poster Presentation Session 1 (Odd), Networking & Exhibition

End of the Day

Session Chair:

OC07 - Hydrophilic and Lipophilic Derivatives of Protulactone A: Synthesis, Antiproliferative Activity and Sar Analysis
Winner of the young medicinal chemist meeting in Serbia

OC08 - Advances in the Development of Novel Therapeutics Targeting Neurodegenerative Diseases
Winner of the young medicinal chemist meeting in Germany (DPhG)

OC09 - Design, Synthesis and Biological Evaluation of Novel P53 Activators by Targeting P53 Protein-Protein Interactions
Winner of the young medicinal chemist meeting in Portugal

OC10 - Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast
Winner of the young medicinal chemist meeting in Israël

Flash Poster Presentations (Part II)

FP11 - Antibody-Protac Conjugates: An Approach for Targeted Selective BRD4 Degradation in HER2+ Phenotypes

FP12 - Preclinical Evaluation of Antibody Recruiting Glycodendrimers (ARGs) for Cancer Therapy

FP13 - Development of Orally Available Cyclic Peptide Therapeutics

FP14 - Sar of Triquinazine, a Class of Potent Janus Kinase Inhibitors

FP19 - Potent and Specific Activators for The Mitochondrial Sirtuins SIRT3 And SIRT5

Coffee Break

Session Chair:

OC11 - A Chemical Biological Approach to Study GPCRS: Labeling the Adenosine A1 Receptor Using an Electrophilic Covalent Probe
Winner of the young medicinal chemist meeting in The Netherlands

OC12 - Indole and Pyrazole as Versatile Scaffolds for Biological Active Compounds: New Chimeric Kinase and Bromodomain Inhibitors
Winner of the young medicinal chemist meeting in Greece

OC13 - The Complementarity Principle in Docking Procedures: Evaluation of the Correctness of Binding Poses
Winner of the young medicinal chemist meeting in Croatia

OC14 - Development of Multifunctional Buche Inhibitors and 5-HT6R Antagonists with Beta-Amyloid Anti-Aggregation Properties as Potential Disease-Modifying Agents against Alzheimer’s Disease
Winner of the young medicinal chemist meeting in Poland

Lunch, Networking & Exhibition

EFMC-YMCS Poster Presentation Session 2 (Even)

Session Chair:

OC15 - Breaking the Paradigm: Radiolabelled CCK₂R Antagonists Are Superior to Radiolabelled Agonists in In Vivo Setting
Winner of the young medicinal chemist meeting in Slovenia

OC16 - Discovery, Characterization and Engineering of Ligases for Amide Synthesis
Winner of the young medicinal chemist meeting in United Kingdom

OC17 - Design, Synthesis, and Preliminary Biological Evaluation of New Boronic Acids Derivatives
Winner of the young medicinal chemist meeting in Czech Republic

OC18 - Unravelling HIDO1 Conformational Dynamic to Guide the Discovery of New Inhibitors
Winner of the young medicinal chemist meeting in Belgium (SRC)

OC19 - Fighting Chemistry with Chemistry - New Antidotes against Nerve Agent Intoxication
Winner of the young medicinal chemist meeting in Sweden

Voting Break

KL02 - Medicinal Chemistry Today: Be Prepared for the Unexpected!

Closing and Award Ceremony

End of the Symposium

Session Chair:

EFMC-YSN Soft Skills Training (1) - Reaxys Workshop: A Tandem Tour to Unveil the Profile of An Active Molecule

EFMC-YSN Soft Skills Training (2) - Reaching Out: Effective Communication and Networking for Scientists

End of the Optional Programme