EFMC-YMCS 2022

9th EFMC Young Medicinal Chemists' Symposium

 Nice, France    September 8-9, 2022

Programme



14:15

Registration

15:00

Welcome and Opening

Dr Maria DUCA
UNIVERSITY OF CÔTE D'AZUR, Nice, France
Prof. Rui MOREIRA
UNIVERSITY OF LISBON, Lisbon, Portugal
15:15

KL01 - "All Models are Wrong, Some are Useful". The Medicinal Chemist is Never Better Than the Biological Models Available to Assess Compound Properties

Prof. Benoit DEPREZ
INSTITUT PASTEUR DE LILLE, Lille, France

EFMC-YMCS Competition Presentation Session I

Session Chair:

Dr Maria DUCA
UNIVERSITY OF CÔTE D'AZUR, Nice, France
15:45

OC01 - Degrading Into Opportunities: Self-Immolation as Mechanism for Artificial Signal Transduction
Winner of the young medicinal chemist meeting in Denmark

Dr Kaja BORUP LØVSCHALL
TECHNICAL UNIVERSITY OF DENMARK, København Ø, Denmark
16:05

OC02 - From a Helix to a Cycle: Peptide Macrocylization Strategies to Develop New Antimicrobial Agents
Winner of the young medicinal chemist meeting in Italy

Prof. Francesco MERLINO
UNIVERSITY OF NAPLES, FEDERICO II, Italy
16:25

OC03 - Disruption of Mitochondrial Redox Homeostasis by Enzymatic Activation of a Trialkylphosphine Probe
Winner of the young medicinal chemist meeting in Switzerland

Ms Jade NGUYEN
EPFL, Geneva, Switzerland
16:45

Flash Poster Presentations (Part I)

FP01 – Triazine-Based Small Molecules as Novel PD-L1 Modulators

Ms Giulia ASSONI
UNIVERSITY OF TRENTO, Trento, Italy

FP02 - Synthesis and Preclinical Validation of Limks Inhibitors: Promising Drugs for Osteosarcoma Treatment?

Mr Rayan BERABEZ
UNIVERSITÉ D'ORLÉANS, ORLEANS, France

FP03 - Development of Encoded Combinatorial Chemistry for The Identification of Specific Ligands of G-Quadruplex DNA Structures

Dr Gilles DEGOTTE
I2BM/UNIVERSITY GRENOBLE ALPES, Grenoble, France

FP04 - Synthesis and Biological Activity of Novel Azoniaspiro Type Quaternary Fluoroquinolones

Dr Joanna FEDOROWICZ
MEDICAL UNIVERSITY OF GDANSK, Gdansk, Poland

FP05 - Development of Novel Necroptosis Inhibitors Targeting RIPK1

Ms Lara FIDALGO
FF.ULISBOA, Lisboa, Portugal

FP06 - Discovery of JNJ-1245, a Novel and Potent Fluoroallylamide MCL-1 Inhibitor for the Treatment of Hematologic Malignancies

Dr Soufyan JERHAOUI
JANSSEN PHARMACEUTICA NV, Beerse, Belgium

FP07 - Target-Directed Dynamic Combinatorial Chemistry Towards the Discovery of Sars-Cov-2 Anti-Virals Targeting NSP10

Dr Gwenaelle JÉZÉQUEL
HZI, Saarbrücken, Germany

FP08 - Panicein a Hydroquinone and Analogs Overcome Chemotherapy Resistance in Cancer Cell

Mrs Sandra KOVACHKA
UNIVERSITÉ COTE D'AZUR, Nice, France

FP09 - Development of Bioorthogonal Palladium Catalysed Reactions for Specific Anticancer Drug Delivery

Ms Marine LEFEVRE
UCLOUVAIN, Louvain la Neuve, Belgium

FP10 - Design, Synthesis & Evaluation of Novel Aminopeptidase Inhibitors as Potent Antimalarials

Ms Mahta MANSOURI
MONASH INSTITUTE OF PHARMACEUTICAL SCIENCES, Parkville, Australia

FP15 - Synthesis and Biological Evaluation of Schistosoma Mansoni Sirtuin2 (SMSIRT2) Inhibitors

Dr Beatrice NOCE
SAPIENZA, UNIVERSITY OF ROME, Rome, Italy

FP16 - Design, Synthesis and Biological Evaluation of New Rna Ligands Targeting miRNA-210: Modulation of the Circadian Clock for Cancer Therapy

Mr Marc PANOSETTI
INSTITUT DE CHIMIE DE NICE - UNIVERSITÉ COTE D'AZUR, Nice, France

FP17 - A Small Fluorescent Ligand to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells

Ms Julia SCHOENFELD
GOETHE-UNIVERSITY, Frankfurt am Main, Germany

FP18 - Bactericidal Autophagy Inhibitors to Treat Recurrent Infections and Cancer

Mrs Alessandra UGOLINI
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IIT), Genoa, Italy
17:15

Coffee Break & Exhibition

EFMC-YMCS Competition Presentation Session II

Session Chair:

Dr Michele MARI
UNIVERSITY OF URBINO, Urbino, Italy
17:35

OC04 - Epitope Identification, a Case Study: Nanobodies Binding to MGLU5 Receptor
Winner of the young medicinal chemist meeting in France

Ms Floriane ESHAK
UNIVERSITY PARIS CITÉ, paris, France
17:55

OC05 - Studies on the Synthesis and Anticancer Potential of Novel 2,4-Diaminopyrimidine Derivatives
Winner of the young medicinal chemist meeting in Turkey

Mrs Deniz LENGERLI
GAZI UNIVERSITY FACULTY OF PHARMACY, Ankara, Turkey
18:15

OC06 - Unraveling the Potential of Multicomponent Reactions in Drug Discovery
Winner of the young medicinal chemist meeting in Spain

Mr Pau Nadal RODRÍGUEZ
UNIVERSITY OF BARCELONA, Barcelona, Spain
18:35

EFMC-YMCS Poster Presentation Session 1 (Odd), Networking & Exhibition

20:30

End of the Day

EFMC-YMCS Competition Presentation Session III

Session Chair:

Dr Stéphane AZOULAY
UNIVERSITY OF CÔTE D'AZUR, Nice, France
08:40

OC07 - Hydrophilic and Lipophilic Derivatives of Protulactone A: Synthesis, Antiproliferative Activity and Sar Analysis
Winner of the young medicinal chemist meeting in Serbia

Ms Sanja DJOKIC
UNIVERSITY OF NOVI SAD, Novi Sad, Serbia
09:00

OC08 - Advances in the Development of Novel Therapeutics Targeting Neurodegenerative Diseases
Winner of the young medicinal chemist meeting in Germany (DPhG)

Dr Steffen POCKES
UNIVERSITY OF REGENSBURG, Regensburg, Germany
09:20

OC09 - Design, Synthesis and Biological Evaluation of Novel P53 Activators by Targeting P53 Protein-Protein Interactions
Winner of the young medicinal chemist meeting in Portugal

Dr Margarida ESPADINHA
UANTWERPEN, Antwerp, Belgium
09:40

OC10 - Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast
Winner of the young medicinal chemist meeting in Israël

Mr Jaber QAIS
TEL AVIV UNIVERSITY, taiybe, Israel
10:00

Flash Poster Presentations (Part II)

FP11 - Antibody-Protac Conjugates: An Approach for Targeted Selective BRD4 Degradation in HER2+ Phenotypes

Dr Maria MANEIRO
UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, Santiago de Compostela, Spain

FP12 - Preclinical Evaluation of Antibody Recruiting Glycodendrimers (ARGs) for Cancer Therapy

Dr Angela MARTIN SERRANO ORTIZ
UNIVERSITÉ GRENOBLE-ALPES, Grenoble, France

FP13 - Development of Orally Available Cyclic Peptide Therapeutics

Mr Manuel MERZ
SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE (EPFL), Lausanne, Switzerland

FP14 - Sar of Triquinazine, a Class of Potent Janus Kinase Inhibitors

Ms Kleni MULLIRI
UNIVERSITY OF BERN, Bern, Switzerland

FP19 - Potent and Specific Activators for The Mitochondrial Sirtuins SIRT3 And SIRT5

Dr Clemens ZWERGEL
UNIVERSITY OF ROME LA SAPIENZA, Rome, Italy
10:10

Coffee Break

EFMC-YMCS Competition Presentation Session IV

Session Chair:

Dr Maja BEUS
INSTITUTE FOR MEDICAL RESEARCH, Zagreb, Croatia
10:40

OC11 - A Chemical Biological Approach to Study GPCRS: Labeling the Adenosine A1 Receptor Using an Electrophilic Covalent Probe
Winner of the young medicinal chemist meeting in The Netherlands

Mr Bert BEERKENS
LEIDEN UNIVERSITY, Leiden, The Netherlands
11:00

OC12 - Indole and Pyrazole as Versatile Scaffolds for Biological Active Compounds: New Chimeric Kinase and Bromodomain Inhibitors
Winner of the young medicinal chemist meeting in Greece

Mrs Amalia KALAMPALIKI
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece
11:20

OC13 - The Complementarity Principle in Docking Procedures: Evaluation of the Correctness of Binding Poses
Winner of the young medicinal chemist meeting in Croatia

Dr Hrvoje RIMAC
UNIVERSITY OF ZAGREB, Zagreb, Croatia
11:40

OC14 - Development of Multifunctional Buche Inhibitors and 5-HT6R Antagonists with Beta-Amyloid Anti-Aggregation Properties as Potential Disease-Modifying Agents against Alzheimer’s Disease
Winner of the young medicinal chemist meeting in Poland

Mr Tomasz WICHUR
UNIWERSYTET JAGIELLONSKI COLLEGIUM MEDICUM , Krakow, Poland
12:00

Lunch, Networking & Exhibition

12:30

EFMC-YMCS Poster Presentation Session 2 (Even)

EFMC-YMCS Competition Presentation Session V

Session Chair:

Dr Kristina GONCHARENKO
ZIFO RND SOLUTIONS, Basel, Switzerland
13:45

OC15 - Breaking the Paradigm: Radiolabelled CCK2R Antagonists Are Superior to Radiolabelled Agonists in In Vivo Setting
Winner of the young medicinal chemist meeting in Slovenia

Ms Doroteja NOVAK
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia
14:05

OC16 - Discovery, Characterization and Engineering of Ligases for Amide Synthesis
Winner of the young medicinal chemist meeting in United Kingdom

Mr Michael ROWLINSON
UNIVERSITY OF MANCHESTER, Manchester, United Kingdom
14:25

OC17 - Design, Synthesis, and Preliminary Biological Evaluation of New Boronic Acids Derivatives
Winner of the young medicinal chemist meeting in Czech Republic

Mr Petr SLECHTA
CHARLES UNIVERSITY, Hradec Králové, Czech Republic
14:45

OC18 - Unravelling HIDO1 Conformational Dynamic to Guide the Discovery of New Inhibitors
Winner of the young medicinal chemist meeting in Belgium (SRC)

Ms Manon MIRGAUX
UNIVERSITÉ DE NAMUR, Namur, Belgium
15:05

OC19 - Fighting Chemistry with Chemistry - New Antidotes against Nerve Agent Intoxication
Winner of the young medicinal chemist meeting in Sweden

Mr Norman HOSTER
UMEA UNIVERSITY, Umea, Sweden
15:25

Voting Break

15:40

KL02 - Medicinal Chemistry Today: Be Prepared for the Unexpected!

Dr Gerhard MÜLLER
ANAVO THERAPEUTICS, Heidelberg, Germany
16:10

Closing and Award Ceremony

16:30

End of the Symposium

Optional Programme

Session Chair:

Dr Kristina GONCHARENKO
ZIFO RND SOLUTIONS, Basel, Switzerland
16:45

EFMC-YSN Soft Skills Training (1) - Reaxys Workshop: A Tandem Tour to Unveil the Profile of An Active Molecule

Dr Giulia MONCELSI
ELSEVIER LIFE SCIENCES, Amsterdam, The Netherlands
17:30

EFMC-YSN Soft Skills Training (2) - Reaching Out: Effective Communication and Networking for Scientists

Dr David PERALTA
CHEMMEDCHEM/CHEMISTRY EUROPE, Weinheim, Germany
18:15

End of the Optional Programme