6th EFMC Young Medicinal Chemists' Symposium
Athens, Greece September 5-6, 2019
Registration
Welcome and Opening
Session Chair:
KL01 - The Emergence of Antibody-Drug Conjugates (ADCs) as Targeted Cancer Therapies: From Ehrlich's "Magic Bullet" Concept to Calicheamicin γ1I and Mylotarg
OC01 - Functionalization of Tumour-Targeting Antibodies Via Enzymatic Oxidation of Tyrosine to 1,2-Quinones
Winner of the Young Medicinal Chemist Meeting in The Netherlands
OC02 - Synthetic Small Molecules Interfering with Oncogenic Micrornas for the Induction of Glioblastoma Stem Cells Differentiation
Winner of the Young Medicinal Chemist Meeting in France
OC03 -New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies to Fight Metastatic Breast Cancer
Winner of the Young Medicinal Chemist Meeting in Portugal
Flash Poster Presentations (01-10)
FP01 - A New Life for Diazaborines: the Next Generation of Serine Protease Inhibitors
FP02 - From Peptides to Peptidomimetics: Structure-Activity Relationship of a Factor H-Binding Peptide to Modulate Undesired Host Complement Activity
FP03 - Matrix Metalloproteinase-12 Inhibitors: Synthesis, Structure-Activity Relationships and Intestinal Absorption of Novel Sugar-Based Biphenylsulfonamide Carboxylates
FP04 - Photophysical Properties and Antiparasitic Activity of Bodipy-Tethered Dinuclear Trithiolato-Bridged Ruthenium(II)-Arene Complexes
FP05 - N-ALKYL L-Iminosugars as Novel Anti-Inflammatory and Anti-Biofilm Tools for Cystic Fibrosis Lung Infections
FP06 - Design, Synthesis and Biological Evaluation of Novel Substituted Purine Isosters as EGFR Kinase Inhibitors, with Promising Pharmacokinetic Profile and In Vivo Efficacy
FP07 - Metal-Chelating Acetohydroxamic Acids Against Hepatitis C Virus and Flaviviruses
FP08 - Discovery of Small-Molecule Modulators of 14-3-3 PPIs Via Dynamic Combinatorial Chemistry
FP09 - Purine Nucleoside Analogs as Highly Potent Leads for the Treatment of Human African Trypanosomiasis
FP10 - Development of Allosteric Inhibitors of ColH Using DCC Strategy
Coffee Break
Session Chair:
OC04 - Novel Acridine Derivatives as TDP 1 and/or 2 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Greece
OC05 - Discovery of a Novel Chemotype of Non-Acidic, Neutral and Macrocyclic Keap1 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Sweden
OC06 - Directed Evolution of Short Peptides for Selective Detoxification of Lead
Winner of the Young Medicinal Chemist Meeting in Switzerland
Flash Poster Presentations (11-20)
FP11 - Identification, Synthesis and Optimization of Inhibitors of the Protein Tyrosine Phosphatase SHP2
FP12 - Multitarget Triazoles: an Innovative Approach for the Treatment of Alzheimer’s Disease
FP13 - TDP-43 Modulation by CDC7 Inhibitors as a Therapeutic Strategy for Amyotrophic Lateral Sclerosis
FP14 - Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool in the Development of Selective Ligands for Subtypes Ampa Receptor
FP15 - In Vitro and In Ovo Evaluation of Ros-Activatable Anticancer Boronate Prodrugs of Doxorubicin
FP16 - Design and Synthesis of Tead's Ligands for the Treatment of Cancers
FP17 - Drug-Fragment Based Explorations for Novel Enterovirus Inhibitors
FP18 - Gemcitabine-GnRH Bioconjugates Bearing Oxime Bond Linkages: Synthesis, In Vitro Stability, Drug Release and Cytotoxic Effect
FP19 - Development of GSTO1-1 Inhibitors for the Treatment of Inflammatory Conditions
FP20 - Identification of a Novel Quinoline-Based DNA Demethylating Compound Highly Potent in Cancer Cells
EFMC-YMCS Poster Presentation Session 1 (Odd), Bites & Drinks
EFMC-YMCS Poster Presentation Session 2 (Even), Bites & Drinks
End of the Scientifc Programme
How to Boost Your Oral Presentation Skill, and Create a Good Slideshow
Getting the Job You Deserve!
EFMC-YSN Networking Event
End of the Day
Session Chair:
KL02 - Medicinal Chemistry Between Serendipity and (Artificial) Intelligence
OC07 - Antiplasmodial Activity of SAHAquines, Novel SAHA - Primaquine Hybrids
Winner of the Young Medicinal Chemist Meeting in Croatia
OC08 - Hybrdization Approach Towards Novel Antituberculars: Design, Synthesis, And Antimicrobial Evaluation Hybrid Compounds Combining Pyrazinamide and p Aminosalicylic Acid
Winner of the Young Medicinal Chemist Meeting in Czech Republic
OC09 - Synthesis, Computational and Biological Evaluation of Novel Benzimidazole Compounds for the Treatment of Cryptococcus Neoformans
Winner of the Young Medicinal Chemist Meeting in the United Kingdom
OC10 - Nʼ-Benzylated Derivatives of N-(7-Chloroquinolin-4-Yl)Octane-1,8-Diamine as Quorum Sensing Inhibitors in Pseudomonas Aeruginosa
Winner of the Young Medicinal Chemist Meeting in Serbia
Coffee Break
Session Chair:
OC11 - Geometric Isomers of N-Propargyl-4-Syrylpiperidine Discriminate Between Monoamine Oxidase Isoforms A and B
Winner of the Young Medicinal Chemist Meeting in Slovenia
OC12 A Fusing Strategy Application: Towards Potent ChE Inhibitors With MTDL Profile
Winner of the Young Medicinal Chemist Meeting in Turkey
OC13 - Development of Unique Molecular Probes: Low-Basicity Agonists for the Study of 5-HT7 Receptor Function
Winner of the Young Medicinal Chemist Meeting in Poland
OC14 - The Establishment of Tocopherol Reference Intervals for Hungarian Adult Population Using Validated HPLC Method
Winner of the Young Medicinal Chemist Meeting in Hungary
Lunch
Why Was My Paper Rejected? Tips from an Editor on How to Get Published
Session Chair:
OC15 - Expanding the Chemical Space of DNA-Encoded Small Molecule Libraries
Winner of the Young Medicinal Chemist Meeting in Germany
OC16 - Finding the Right Candidate for the Right Position: a Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders
Winner of the Young Medicinal Chemist Meeting in Spain
OC17 - From ZINC to ZINClick: Our Way to Explore the Chemical Space
Winner of the Young Medicinal Chemist Meeting in Italy
OC18 - Extended Glucuronides: Achieving Site-Selectivity Through Extracellular Drug Release
Winner of the Young Medicinal Chemist Meeting in Denmark
OC19 - Cyclopropenium-Based Polymers
Winner of the Young Medicinal Chemist Meeting in Israel
Voting Break
KL03 - Chemical Tools to Target and Image Tumours
Closing and Award Ceremony
End of the Symposium